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Current Topics in Peptide & Protein Research   Volumes    Volume 22 
A pentapeptide analogue of somatostatin as a vector for targeted delivery of radionuclides: А new pathway for the synthesis of a conjugate
Derenik S. Khachatryan, Vasilii N. Osipov, Vasilii M. Retivov, Anton V. Kolotaev
Pages: 145 - 156
Number of pages: 12
Current Topics in Peptide & Protein Research
Volume 22 

Copyright © 2021 Research Trends. All rights reserved

Currently targeted therapy is one of the major methods of medical treatment for cancer. The creation of new radiopharmaceuticals to treat and diagnose neuroendocrine tumors expressing somatostatin receptors is a topical task that is needed to increase their selectiveness and to overcome tumor resistance that occurs. The search for new vectors and more efficient conjugates is required for this goal. A new method of conjugate synthesis based on pentapeptides (somatostatin analogs) containing the aryl-substituted thiazolidinecarboxylic acids was developed. The most optimal ethylenediamine is proposed as a linker, binding the vector with the chelator.
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