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Current Topics in Peptide & Protein Research   Volumes    Volume 23 
Abstract
The anti-amyloidogenic effect of hydroxypropyl-β-cyclodextrin and trans-ferulic acid
Márta Kotormán, István Bohács, Khajidmaa Erdenebileg
Pages: 107 - 111
Number of pages: 5
Current Topics in Peptide & Protein Research
Volume 23 

Copyright © 2022 Research Trends. All rights reserved

ABSTRACT
 
Protein conformational diseases make the lives of millions miserable worldwide. Therefore, it is very important to search for molecules that inhibit protein misfolding. In our experiments, we investigated the anti-amyloidogenic effect of hydroxypropyl-β-cyclodextrin and trans-ferulic acid using α-chymotrypsin as a model protein at neutral pH in the presence of 55% ethanol. Both inhibitors proved to be effective in inhibiting aggregation and their effect was exerted in a concentration-dependent manner. Trans-ferulic acid has proven to be a very powerful anti-aggregation agent, as it almost completely eliminated the presence of aggregates in the sample at a concentration of 10 mM.
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