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Current Topics in Biochemical Research   Volumes    Volume 23 
Abstract
The use of dodecyltrimethylammonium bromide as penetration enhancer in the development of intranasal formulation in equines
Velloso María Inés, Landoni María Fabiana
Pages: 79 - 81
Number of pages: 3
Current Topics in Biochemical Research
Volume 23 

Copyright © 2022 Research Trends. All rights reserved

ABSTRACT
 
The aim of this research was to evaluate the effect of dodecyltrimethylammonium bromide (DTAB) on in vitro permeation of butorphanol through equine nasal mucosa. In vitro permeation studies were done using Franz type diffusion cells and equine mucosa. Two formulations were compared, a control formulation and a formulation containing dodecyltrimethylammonium bromide (DTAB) as penetration enhancer (FI). Flux values at the steady state (Jss), apparent permeability coefficients (Kp) and lag-time were obtained from the cumulative amount of butorphanol that permeated through equine nasal mucosa and a statistical comparison was performed. The values of Jss, Kp and lag-time obtained using control formulation and FI did not show statistically significant differences. The addition of DTAB at a concentration of 0.030% W/V is not favourable in the development of intranasal formulations of butorphanol, because it does not improve the passage of butorphanol through equine nasal mucosa.
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