While the world is grappling with the SARS-CoV-2 pandemic and striving to minimize the damage caused, another emerging virus called Monkeypox Virus (MPXV) has surfaced, capturing widespread attention and instilling panic among people. There is a fear that this new virus could lead to a scenario similar to, if not worse than, the ongoing COVID-19 crisis. Hence, the objective of this work is to provide an overview of the monkeypox disease to shed light on the characteristics and behavior of this emergent disease, to explore reliable and possible diagnostic methods, and delve into the available preventive and therapeutic measures, including viable drugs and approved vaccines, to mitigate the impact of the illness. Many enigmas still surround this emergent disease, which makes it crucial to emphasize the importance of clarifying its progression and establishing effective control measures; by doing so, we can learn from past experiences and avoid repeating the errors that occurred during the COVID-19 pandemic.