ABSTRACT Muscarinic M3-receptors, α1-adrenoceptors and histamine H1-receptors can be divided into two subtypes discriminated by the β-chloroethylamines propylbenzilylcholine mustard (PrBCM), chloroethylclonidine (CEC) and phenoxybenzamine (PBZ), only in the presence of GTP of GTPγS. The full agonists interact with both subtypes to induce responses. The partial agonists activate one of them to induce responses but behave as competitive antagonists when they interact with the other. Figures (Fig. 8 and 18) in the full paper show the modification of the classical drug receptor mechanisms.
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