Many organic and inorganic compounds cross the hepatic cell plasma membrane in both directions. The liver plays an important role in the clearance of different compounds from the blood stream. Consequently, much attention has been paid to the physicochemical and energetic mechanisms governing hepatic uptake. This review will focus mainly on the role of plasma membrane carriers accounting for liver uptake of long chain free fatty acids, bile acids and non-bile acids cholephilic organic anions. The different transporters identified by the classical and the molecular approach are described.
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