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Trends in Entomology   Volumes    Volume 3 
The NC mouse as a model for atopic dermatitis - A role of the mite antigen in its pathogenesis
Teruaki Ikeda, Yosaburo Oikawa, Yoshiro Ohara
Pages: 105 - 111
Number of pages: 7
Trends in Entomology
Volume 3 

Copyright © 2003 Research Trends. All rights reserved


NC mice, which were established as an inbred strain on the background of Japanese fancy mice, develop an atopic dermatitis(AD)-like skin lesion with IgE  hyperproduction (NC dermatitis) when bred in conventional conditions.  This disease serves as a model for human AD.  Various factors have been speculated to be involved in the induction of NC dermatitis, but none have been clearly implicated.  Interestingly, experimental infestation of Myobia musculi or Myocoptes musculinus induces dermatitis with hyperproduction of IgE in NC mice, which is clinically and pathologically similar to NC dermatitis.  The eradication of mites reduces serum IgE level and improves the dermatitis.  These data strongly suggest that mite antigen is one of the factors regulating the onset of AD-like skin lesion in NC mice.  A further understanding of the relationship of mite antigen to NC dermatitis will elucidate the pathogenesis of human AD and identify effective treatments.

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