An overview of the solubilization properties that we have studied in reverse miscelles is presented in this contribution. The role of specific interactions such as hydrogen bonding and electron donor acceptor (EDA) complexation between different solutes and reverse micelles systems as well as the characteristics of the microenvironment are reviewed. The importance of these interactions to evaluate properties of the micelles interfaces is stressed. Studies of micropolarity by using optical probes such as 1-methyl-8-oxyquinolinium betaine (QB) and 2,6-diphenyl-4-(2,4,6-triphenyl-1-pyridinio) phenoxide (E_r(30)), are presented. These molecular probes are located in the micellar interface and QB can sense polarity and hydrogen bond donor capability of the microenvironment. The properties of the probes to detect the micropolarity of cationic and nonionic reverse micelles in different solvents are also considered. The hydrogen bond acceptor ability of AOT in reverse micelles is reviewed. The strength of binding is interpreted considering the hydrogen bond donor ability of the different solutes as well as their solubility in the pure solvent. The dependence on the water content is also explained. The electron donor properties of AOT have been proposed for several probes. In particular the interactions of AOT with iodine and tetracyanothylene (TCNE) are reported in detail. The complexes seem to be form at the micellar interface showing microenvironment polarity dependence. Water contents seem to decrease the magnitude of these interactions.