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Current Topics in Toxicology   Volumes    Volume 3 
Synthesis of a naphtalene endoperoxide as a source of 17O-labeled singlet molecular oxygen for mechanistic studies: chemical trapping, NMR and mass spectrometry analysis
Miriam Uemi, Glaucia R. Martinez, Marisa H. G. Medeiros, Paolo Di Mascio
Pages: 89 - 103
Number of pages: 15
Current Topics in Toxicology
Volume 3 

Copyright © 2006 Research Trends. All rights reserved

The cell damage caused by singlet molecular oxygen (1O2) has been extensively studied for a long time using different sources of 1O2. It was shown that 1O2 is very reactive towards many electron-rich organic functions and biological targets like lipids, proteins and DNA. Here is presented the synthesis of N,N’-di(2,3-dihidroxypropyl)-1,4-naphthalenedipropanamide (DHPN17O2) and 9,10-diphenylanthracene (DPA17O2) endoperoxides labeled with 17O2. The ability of DHPN17O2 to act as a source of [17O]-labeled singlet oxygen was checked by using water soluble disodium salt of anthracene 9,10-diyldiethyl disulfate (EAS) and linoleic acid as  chemical traps of 1O2.
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