Recurrence of subacute thyroiditis has been known to be rare. In particular, there have been only limited case reports of late recurrence over 20 years after a complete recovery. We describe a case of 61-year-old female patient who had late recurrence of subacute thyroiditis. Our case is worthy publishing in respect that the serum levels of TSH, and either free triiodo- thyronine (FT₃) or free thyroxine (FT₄) were within normal range against typical symptoms and signs suggestive of hyperthyroid phase, and the patient developed the second episode of subacute thyroiditis over 22 years after a complete recovery.