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Current Trends in Medicinal Chemistry   Volumes    Volume 3 
Abstract
Syntheses of oxetanocin A and related unusual nucleosides with four-membered heterocyclic sugars as potential antiviral agents
Eiko Ichikawa, Kuniki Kato
Pages: 101 - 119
Number of pages: 19
Current Trends in Medicinal Chemistry
Volume 3 

Copyright © 2003 Research Trends. All rights reserved

ABSTRACT

In 1986 a remarkably unusual nucleoside, oxetanocin A (OXT-A) was isolated from the fermentation broth of Bacillus megaterium, and the structural investigation and X-ray crystallographic analysis revealed that OXT-A was the first natural nucleoside having an oxetane ring as a sugar moiety. More interestingly, OXT-A exhibited potent antiviral activity against HSV-1, HSV-2, HCMV, and HIV-1. In this review we will give an overview of the synthetic efforts of OXT-A from the first synthesis in 1987 and the related unusual nucleosides with four-membered heterocyclic sugars as potential antiviral agents, including our works in this area.

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