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Current Trends in Medicinal Chemistry   Volumes    Volume 3 
Abstract
Synthesis and properties of N-alkylsubstituted zinc (II) phthalocyaninates as potential agents for photodynamic therapy
Cristian A. Strassert, Myriam E. Rodriguez, Daniel A. Fernández, Lelia E. Dicelio, Josefina Awruch
Pages: 165 - 173
Number of pages: 9
Current Trends in Medicinal Chemistry
Volume 3 

Copyright © 2003 Research Trends. All rights reserved

ABSTRACT

The synthesis, photophysical properties and phototoxicity of N-alkylsubstituted zinc (II) phthalocyaninates were evaluated as potential agents for photodynamic therapy. Fluorescence, triplet and singlet oxygen quantum yields were measured and photophysical characterization of the triplet state was performed for these dyes. These parameters were calculated based on aggregation results as well as with phthalocyaninate incorporation into microheterogeneous and hydrosoluble media.

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