Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 4 
Ionic mechanisms and molecular basis of human cardiac repolarization: implications for drug development
Zhiguo Wang
Pages: 19 - 35
Number of pages: 17
Current Topics in Pharmacology
Volume 4 

Copyright © 1998 Research Trends. All rights reserved

Electrical activity is a fundamental phenomenon of living cardiac cells. The normal function of the heart relies on normal electrical activity of the heart itself. Cardiac electrical disorders are a cause of considerable morbidity and morality. Although tremendous efforts have been made to improve the therapeutic outcome of arrhythmias, current treatments are still inadequate. Part of the reason is our insufficient understanding of the nature of the ion channel proteins and the mechanisms by which these channel proteins govern the electrical activity of the heart at the molecular level. Because of this, ever-growing efforts are being made to exploit unsolved mysteries and to fight new problems, by researchers from all over the world with their talent, their elegant approaches, and their sophisticated techniques. In particular, studies utilizing human cardiac preparations have yielded enormous amount of useful information awaiting for integral analysis so that it could be applied to clinical medicine and drug development. This review article attempts to compile and summarize work that the author was involved in and work completed by other researchers. Characteristics of human cardiac AP are introduced, with emphasis on the interspecies differences and regional variations. Pathological alterations and pharmacological properties of human AP are also described. Basic biophysical properties of five major repolarizing K+ currents (Ito1, IKur, IKr, IKs, and IK1) and their physiological roles and pathological alterations are summarized. Studies on the potential molecular composition of these native K+ channels are mentioned. And finally, the potential implications of studies on the ionic mechanisms and molecular basis in new drug development for treatment of cardiac electrical disorders are discussed. The goal of this article is to try to help researchers and pharmaceutical companies to make full use of information provided by recent advance in molecular biology.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms