ABSTRACT Four series of imidazo [1,2-b]pyridazine acidic derivatives, namely 2-phenylimidazo [1,2-b]pyridazine-3-carboxylic acids (4w), 2-methylimidazo[1,2-b]pyridazine-3-carboxylic acids (4x), imidazo[1,2-b]pyridazine-2-acetic acids (4y) and imidazo[1,2-b]pyridazine-2-carboxylic acids (4z),were synthesized via a common synthetic method. Their antiinflammatory, analgesic and ulcerogenic activities were evaluated. Pharmacological results were examined and discussed in order to find structure-activity relationships.
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