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Current Topics in Virology   Volumes    Volume 4 
Abstract
Pathophysiology of Rotavirus diarrhea
Ove Lundgren, Lennart Svensson
Pages: 51 - 61
Number of pages: 11
Current Topics in Virology
Volume 4 

Copyright © 2004 Research Trends. All rights reserved

ABSTRACT

Rotavirus diarrhea is a major cause of infantile gastroenteritis worldwide. This review is mainly devoted to the effects of Rotavirus on intestinal epithelial transport. The virus decreases intestinal uptake of water, electrolytes, glucose and amino acids by attenuating the functions of transport symports of epithelial cells and of the brush border enzymes as well as by increasing intestinal permeability. Furthermore, net fluid secretion is increased via an action of a Rotavirus enterotoxin (NSP4) and by a stimulation of secretory reflex(es) in the enteric nervous system.

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