ABSTRACTCholesterol rich domains have been identified as regions of the membrane which play an important role in the entry, assembly and release of several viruses e.g. HIV-1, the ecotropic Moloney murine leukaemia virus and measles virus. We will summarize recent results on the assembly of murine retroviruses (ecotropic and amphotropic) and lentivirus HIV-1. For assembly viral components are concentrated in lipid rafts as well as foreign proteins and both are incorporated into the budding virus. We will focus on the factors determining transport to and association with lipid rafts and discuss the role of caveolin, the defining protein of cellular invaginations termed caveolae, which has been found to be incorporated into amphotropic 4070 A viruses.
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