ABSTRACT During the first 24 hours of hypoxia induced by the closure of valves, the Fru-6-P/Fru-1, 6.P2 pathway accelerates. After, the metabolic depression takes place and can be explained by the fall in the intracellular pH value concomitant with the decrease in the Fru-2,6-P2 levels. Phosphorylation of regulatory enzymes could be considered as a regulatory potential when it is demonstrated the existence of molecules that stimulate receptors of the phenomenon before pO2 fall.
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