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Current Topics in Pharmacology   Volumes    Volume 5 
Nitric oxide generation via G protein-coupled receptors
Arthur Christopoulos, Adolfo E. Cuadra, Esam E. EI-Fakahany
Pages: 31 - 44
Number of pages: 14
Current Topics in Pharmacology
Volume 5 

Copyright © 2000 Research Trends. All rights reserved


Nitric oxide is a highly reactive free radical gas that has been implicated in a growing array of physiological and pathophysiological states. This signaling molecule represents a common component of the transduction pathways of a number of neurotransmitters that act via binding to G protein-coupled receptors, and an intense research effort into the elucidation of its molecular mechanisms of action is currently underway. The extreme lability of this substance necessitates a tight degree of nitric oxide regulation that is required in order to maintain appropriate cellular homeostasis. This review discusses some of the inter- and intracellular roles of nitric oxide, particularly with regard to their relationship to G protein-coupled receptor activation.

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