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Current Topics in Pharmacology   Volumes    Volume 5 
Molecular mechanisms of action of positive inotropic agents that increase responsiveness of cardiac myofilaments to Ca2+
Yoshimi Kitada, Hisashi Kawasumi
Pages: 109 - 117
Number of pages: 9
Current Topics in Pharmacology
Volume 5 

Copyright © 2000 Research Trends. All rights reserved


There is much evidence that contractility is depressed in failing heart. However, the use of interventions that arguments the contractile force by increasing an intracellular free Ca2+ ion has not been a success in treatment with chronic heart failure. Unfortunately these drugs are associated with an increased risk of mortality. New inotropic agents (pimobendan, levosimendan, MCI-154, EMD57033 and CGP48506) have been developed that increase the responsiveness of contractile proteins to Ca2+ These drugs can exert force of contraction without inducing arrhythmia and increasing energy consumption by Ca2+ overload. Therefore these classes of drugs are defined as Ca2+ sensitizers and are expected as a possible pharmacotherapy for chronic heart failure. The Ca2+ sensitizers divide into three classes dependent of their mode of action. The present article reviews the molecular mechanisms of action of Ca2+ sensitizers.

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