Pancreatic polypeptide (PP) family consists of neuropeptide Y (NPY), PP and peptide YY (PYY). Recent studies indicate that PP and PYY released after injestion of food affect gut motility and secretion via specific receptors in the dosal vagal complex (DVC) of the brain stem as a feedback mechanism. We have recently found that endogenous NPY is involved in the regulation of duodenal motility, producing migrating myoelectrical complex (MMC). We will briefly review the affects of PP family peptides on gut motility as a typical example of brain-gut peptides that are thought to play an important role in the physiological regulation of gut function and its disorders.