The automatic Surface Force Apparatus (SFA) yields some simultaneous information about parameters that control the adsorption of proteins onto a solid/liquid interface in a few nanometers thin gap. As illustration of recent experimental results, we discuss the early steps of aggregation or nucleation of macromolecules, the desorption of proteins from the ultra smooth freshly cleaved surface of mica, the structural behavior of anisotropic macromolecules and the size variations of proteins submitted at a variable compression stress under different chemical conditions.