Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Peptide & Protein Research   Volumes    Volume 5 
Bovine β-lactoglobulin and other lipocalin as the source of bioactive peptides
Jerzy Dziuba, Anna Iwaniak, Marta Niklewicz, Piotr Minkiewicz
Pages: 101 - 104
Number of pages: 4
Current Topics in Peptide & Protein Research
Volume 5 

Copyright © 2003 Research Trends. All rights reserved

Proteins can be a valuable source of peptides with the antihypertensive, antiamnestic, antithrombotic, immunomodulating etc. activity. Bovine ß- lactoglobulin - one of whey milk proteins is regarded as the one of the richest sources of bioactive peptides. The structural similarity of bovine ß- lactoglobulin indicates that the protein belongs to a lipocalin family. Among lipocalins the following proteins can be found: retinol binding protein (RBP), bilin binding protein (BBP), epidermal retinol binding protein (EBP) or odorant binding protein (OBP). In all members of lipocalin family the common motifs  are A-B, B-C, D-E, E-F, F-G, G-H loops as well as the fragments ß-A, ß-B, ß-C, ß-D, ß-E, ß-F, ß-H, and ß-I. Lipocalins with other structural families like avidins, fatty acid binding proteins (FABs) are the part of structural superfamily i.e calycins.
This paper presents computer-aided analysis of 5 proteins belonging to lipocalin family carried out with the help of  database containing 1,100 bioactive peptide sequences. The results have shown that the most of bioactive sequences in all analysed lipocalins were observed in fragments of structures ß-A, ß-G, ß-I and A-B loop. In the above -mentioned motifs the fragments with the following biological activity were found: antihypertensive, opioid, immunomodulating, dipeptidyl peptidase inhibitors, antiamnestic, antithrombotic, stomach mucosal membrane regulating and neuropeptides. Bioactive fragments found in loops were located outside of the protein molecule and fragments found in ß structures inside of it. Such iformation may be meaningful in designing of proteolytic processes in aspect of obtaining the bioactive peptides on industrial scale.


Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms