This brief review aims at enhancing the understanding on the concepts of sleep neurology among neurologists. Because some epileptic disorders exhibit significant wake/sleep dependency, the present manuscript focuses on the effects of sleep on epilepsy. The basic knowledge of sleep is briefly reviewed with special reference to epilepsy. In this review, emphasis is laid on a unique phenomenon, which exhibits significant changes in motor phenomenon in accordance with state changes - response-reversal. In addition, as a clinically applicable index to suggest brain chemical balances, atonia during non-rapid eye movement sleep is also introduced.  Finally, the importance of the recognition of sleep health is emphasized. Epilepsy is concluded to be a useful disease condition to study the area of sleep neurology. Sleep neurology must be a fascinating research area for many neurologists researching epilepsy.