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Current Trends in Medicinal Chemistry   Volumes    Volume 5 
Abstract
Inhibition of protein-protein interactions with low molecular weight compounds
Marilyn M. Matthews, David J. Weber, Paul S. Shapiro, Andrew Coop, Alexander D. MacKerell Jr.
Pages: 21 - 32
Number of pages: 12
Current Trends in Medicinal Chemistry
Volume 5 

Copyright © 2008 Research Trends. All rights reserved

ABSTRACT
 
An overview of issues associated with the design and development of low molecular weight inhibitors of protein-protein interactions is presented. Areas discussed include information on the nature of protein-protein interfaces, methods to characterize those interfaces and methods by which that information is applied towards ligand identification and design. Specific examples of the strategy for the identification of inhibitors of protein-protein interactions involving the proteins p56lck kinase, ERK2 and the calcium-binding protein S100B are presented. Physical characterization of the inhibitors identified in those studies shows them to have drug-like and lead-like properties, indicating their potential to be developed into therapeutic agents.
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