Photodynamic Therapy (PDT) has been employed as a treatment for the eradication of solid tumors. This treatment involves the administration of a photosensitive drug, excited by light of appropriate wavelength, causing localized tumor cell death in the presence of oxygen. A marked feature of PDT-induced cell death is a strong, acute inflammatory host response. Parallel to other inflammatory reactions, the immune response induced by PDT is characterized by edema formation, and the infiltration of inflammatory cells. The first inflammatory cell type to arrive at a site of cell damage is the neutrophil. Accumulating evidence indicates that activated neutrophils sequester in tumors during and following PDT light treatment, and their engagement gives an indispensable contribution to the success of this anti-tumor modality. This review therefore summarizes the role of neutrophils in inflammation and shows how the activity of these cells contributes to the effective eradication of solid tumors by PDT.