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Current Topics in Peptide & Protein Research   Volumes    Volume 6 
Dipeptidyl peptidase IV inhibition in the treatment of diabetes mellitus: lessons from animal models
J. Andrew Pospisilik, Christopher H. S. McIntosh, Hans-Ulrich Demuth, Raymond A. Pederson
Pages: 65 - 70
Number of pages: 6
Current Topics in Peptide & Protein Research
Volume 6 

Copyright © 2004 Research Trends. All rights reserved


Inhibition of the ubiquitous serine peptidase dipeptidyl peptidase IV (DP IV) has attracted much recent attention as a potential therapeutic strategy in the treatment of diabetes. By protecting the full length, biologically active forms of a number of gut peptides, specific DP IV-inhibitors indirectly stimulate multiple hormonal axes effecting enhance β-cell growth, function, and survival as well as improved insulin sensitivity and glucose tolerance. The following provides a synopsis of our own studies examining the effects of long-term DP IV-inhibitor treatment in animal models of diabetes, and the relevance of these findings towards the treatment of type-1 and type-2 diabetes mellitus.

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