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Current Topics in Peptide & Protein Research   Volumes    Volume 6 
Pathophysiological functions of the cryptic activities of protein fragments related to coagulation, fibrinolytic pathways, and to the extracellular matrix
Henri Criseo, Solène Mine, Sandra Dehaudt, Ludmilla Paquay de Plater, Maryline Favier, Marina Cartron, Véronique Ravelojaona, Frédérique Fauvet, Séverine Beuret, Mathieu Gaspard, Charlotte Crépin, Xavier Nissan, Adeline Pézard, Alix de Calignon, Sandrine Charpateau, Edouard Bieth, Michèle Reboud-Ravaux, Maurice Pagano
Pages: 189 - 223
Number of pages: 35
Current Topics in Peptide & Protein Research
Volume 6 

Copyright © 2004 Research Trends. All rights reserved


Many biological activities can be masked in globular and fibrillar proteins. Conformational or proteolytic changes can reveal these cryptic activities. In this review, we summarize the function of these unmasked fragments related to the coagulation/fibrinolytic pathways, and to pathological states involving the extracellular matrix proteins. The review also includes recent findings about the release of cryptic fragments from extracellular matrix proteoglycans.  For example, the tissue-remodeling processes that occur in vascular diseases, angiogenesis, and tumor invasion are dependent on the expression of these cryptic activities. These studies suggest that new therapeutic targets and agents, particularly those involving inhibition of angiogenesis, can be developed using recombinant molecules.

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