ABSTRACT In this paper we described an account of the synthesis of new tetrahydrofuran bioactive compounds, employing functionalized 2-oxabicyclo[3.3.0]octane system, as useful synthon. New analogues of prostacyclin and new bicyclic PAF receptor antagonists were designed and prepared, as possible lead-compound to anti-platelet agents. Additionally, during this work were developed a diastereo and enantioselective method to obtain 2-allyl-2-carboalkoxy-cyclopentanol derivatives, which is the precursor of this important heterocyclic system, exploring the cationic oxidative cyclization process, discovered in our laboratory.
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