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Trends in Heterocyclic Chemistry   Volumes    Volume 6 
Abstract
Planning and synthesis of novel 2-oxabicyclo[3.3.0]octane derivatives as potential lead-compounds with anti-platelet properties
Eliezer J. Barreiro, Carlos A. M. Fraga, Emerson P. Peçanha
Pages: 37 - 48
Number of pages: 12
Trends in Heterocyclic Chemistry
Volume 6 

Copyright © 1999 Research Trends. All rights reserved

ABSTRACT
 
In this paper we described an account of the synthesis of new tetrahydrofuran bioactive compounds, employing functionalized 2-oxabicyclo[3.3.0]octane system, as useful synthon. New analogues of prostacyclin and new bicyclic PAF receptor antagonists were designed and prepared, as possible lead-compound to anti-platelet agents. Additionally, during this work were developed a diastereo and enantioselective method to obtain 2-allyl-2-carboalkoxy-cyclopentanol derivatives, which is the precursor of this important heterocyclic system, exploring the cationic oxidative cyclization process, discovered in our laboratory.
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