ABSTRACT Some new developments of the asymmetric synthesis of C-4 monosubstituted alkyl and aryl, densely funcionalized 2-amino-4H-pyrans, are described. Two complementary strategies have been devised: a) the Michael addition of malononitrile to enantiomerically pure α-acyl, alkylidenepropenoates derived from the chiral pool of natural products, and b) the Michael addition of chiral β-ketosulfoxides to arylidenemalononitriles.
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