Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Virology   Volumes    Volume 6 
Abstract
Structural differences of subunit monomer, self-assembling process of coat protein, reconstitution process of coat protein and RNA of tobacco mosaic virus and its mutant cucumber green mottle mosaic virus
Yoh Sano
Pages: 67 - 94
Number of pages: 28
Current Topics in Virology
Volume 6 

Copyright © 2007 Research Trends. All rights reserved

ABSTRACT
 
Cucumber green mottle mosaic virus (CGMMV) is a rod-shaped virus closely related to tobacco mosaic virus (TMV) in its chemical and immunological characteristics, and also identical in size. Both viruses show an extremely similar tertiary structure in the ordered gels. The coat protein of both viruses has about 37% sequence homology. Despite such a remarkable resemblance between their structures of both viruses and proteins, and between the schemes of the constructions of both viruses, they have fairly different biological activity. When the two constituents of the virus, coat protein and RNA, are cultivated in a greenhouse at the temperature above 30oC, the yield of TMV is much better than CGMMV, and moreover, the former is known to have intensive infectivity than the latter. The question remains, therefore, open why both viruses have such different infectivity. In the present paper, the problems about the structural differences of subunit monomer, different self-assembling process of coat protein, local structural difference of RNA, different reconstitution process of coat protein and RNA from both viruses, different penetration behavior of coat proteins into model membrane are discussed. From these results the antiviral activity of polysaccharides against infection of TMV are then discussed because the large aggregates of TMV in the presence of polysaccharides prevent the penetration of TMV-RNA into the cell membrane and/or the blocking the decapsulation process of TMV coat protein at the earliest infection stage.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms