Ethanol, methanol, water and chloroform extracts of Musa paradisiaca peels [Plantain] were screened for their antibacterial activities against some known pathogens vis-à-vis Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Salmonella typhi. This was determined by zone of inhibition test (ZIT), minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC). Dry sample yielded more extract and had more antibacterial activity than fresh sample extract. Methanol extracts exhibited more antibacterial activity, followed by ethanol and chloroform. Water extracts did not inhibit the test organisms. However, ethanol extract compared favourably with methanol extract in inhibiting the test bacteria. There was no significant difference between methanol and ethanol extract of plantain peel in respect of their antibacterial activity on the test organisms at P < 0.05. Phytochemical screening showed that Musa paradisiaca peel contains tannin, alkaloid, steroid, saponin, flavonoid and carbohydrate while cyanogenic glycoside was absent. It is recommended that methanol and ethanol be used in preference to chloroform and water in extracting active ingredients from plant materials. The fact remains that methanol and ethanol being more volatile than other solvents used in this study can dissolve more active ingredients found in plant extracts.