Reports about vanadium inhalation toxicity on the hematopoietic system are limited, reason why we decided to evaluate vanadium effects on blood counts and morphologic analysis in blood smears. Male mice inhaled V₂O₅ 0.02M twice a week/12w. Samples were obtained by direct heart puncture; smears were used for morphologic evaluation and blood cells quantification. Hemoglobin, hematocrit, total serum proteins and fibrinogen were also evaluated. Normocytic anemia was evidenced, as well as leukocytosis, neutrophilia, lymphocytosis, thrombocytosis and megaplatelets. Fibrinogen, total serum proteins also increased. These findings suggest that inhaled vanadium induces blood modifications that suggest chronic systemic inflammation. Thrombocytosis and fibrinogen increase correlated with thromboembolic diseases that have been associated with suspended particles inhalation. Leukocytosis with neutrophilia and lymphocytosis could also participate in the chronic inflammation, possibly generated as a consequence of oxidative stress induced by vanadium. Further analysis is needed to dissect this phenomena and its implication in human health.