Vanadium is an air pollutant whose concentration has been increasing in the last decades. Previous reports from our laboratory mention its genotoxicity, hematotoxicity and reprotoxicity, but we have not explored the pancreas. Since some vanadium compound have been suggested for treatment of Diabetes Mellitus, we decided to explore the changes in the pancreas in our murine model. After six weeks of inhaled vanadium exposure we identified inflammatory infiltrate, increased zymogen granules, amylasemia and an increment in serum triglycerides. No changes were identified in control mice. With our data we might postulate that atmospheric pollution might be inducing pancreatic changes that in addition of life style could be facilitating acute pancreatitis. More research is needed to identify this association in populations residing in highly polluted cities, mainly in those with high suspended particles.