Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Peptide & Protein Research   Volumes    Volume 7 
Abstract
A model for the mechanism of laminin-mediated neurite outgrowth
Avishek Nandi, Benjamin S. Weeks
Pages: 47 - 51
Number of pages: 5
Current Topics in Peptide & Protein Research
Volume 7 

Copyright © 2005 Research Trends. All rights reserved

ABSTRACT

This is a brief review of the mechanism of laminin-mediated neurite outgrowth in which several key observations are presented with the purpose of developing a model of the key molecular events involved with laminin active site interaction with receptors, signal transduction, cytoskeletal rearrangement, basement membrane remodeling and growth cone extension. This is a thorough review of the known laminin active sites, receptors, signal transduction pathways and alteration in gene expression. However, this review is not designed as a catalog of these events. Instead, this review is designed to link the simultaneous role of laminin both as an adhesion molecule for neurons and as a malleable substrate that growth cones can detach from and move along. Underlying this apparent contradictory function, simultaneous stabilization and destabilization of the cytoskeleton is required for neurite elongation. Here, a model of the mechanism of laminin-mediated neurite outgrowth is developed that illustrates the structural, architectural and biochemical sequence that leads to laminin-mediated neurite outgrowth. 

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms