ABSTRACT The Src homology 2-containing phosphotyrosine phosphatase (SHP2) is a ubiquitously expressed tyrosine phosphatase with two N-terminal SH2 domains, one tyrosine phosphatase domain and two tyrosine phosphorylation sites at the C-terminus. This unique structural organization suggests that SHP2 plays a regulatory role in various Angiotensin II-induced signaling pathways that contribute to normal vascular function and subsequent disease progression. This review discusses the various Ang II signaling pathways involved in maintenance of hemodynamics and SHP2’s involvement in that balance, suggesting that SHP2 may serve as an important therapeutic target for the intervention of signaling pathways associated with cardiovascular diseases.
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