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Trends in Cell & Molecular Biology   Volumes    Volume 7 
Abstract
The molecular functions of SHP2 in angiotensin II mediated signaling pathways
Karl M. Fernstrom, Rebecca Smiley, M. Showkat Ali
Pages: 81 - 88
Number of pages: 8
Trends in Cell & Molecular Biology
Volume 7 

Copyright © 2012 Research Trends. All rights reserved

ABSTRACT
 
The Src homology 2-containing phosphotyrosine phosphatase (SHP2) is a ubiquitously expressed tyrosine phosphatase with two N-terminal SH2 domains, one tyrosine phosphatase domain and two tyrosine phosphorylation sites at the C-terminus. This unique structural organization suggests that SHP2 plays a regulatory role in various Angiotensin II-induced signaling pathways that contribute to normal vascular function and subsequent disease progression. This review discusses the various Ang II signaling pathways involved in maintenance of hemodynamics and SHP2’s involvement in that balance, suggesting that SHP2 may serve as an important therapeutic target for the intervention of signaling pathways associated with cardiovascular diseases.
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