Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Trends in Cancer Research   Volumes    Volume 7 
Abstract
Iron decreases cytotoxicity of vitamin C in Molt- 4 cells
Narendra P. Singh, Khushbu Komal, Ji Sun Park, Arun A. Singh, Thomas E. Gerhardt, Henry C. Lai
Pages: 95 - 103
Number of pages: 9
Trends in Cancer Research
Volume 7 

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
Vitamin C has been suggested to play a beneficial role in the prevention and treatment of cancer.  However, its in vivo efficacy against cancer is inconsistent even at very high doses. We hypothesized that a high concentration of iron may reduce or eliminate the effectiveness of vitamin C cytotoxicity towards cancer cells. Molt-4 (human leukemia) cells and normal human leukocytes were incubated with holotransferrin (0, 1.25, 2.5, or 5 mg/mL) for an hour. Cells were then treated with sodium ascorbate (0, 64, 128, or 256 µM) and live cells were counted after various times of incubation. At concentrations of 256 µM and 128 µM, ascorbate alone killed all Molt-4 cells in 48 hr and 72 hr, respectively (p<0.001, compared to untreated control), without significantly affecting leukocytes (p>0.05). Preincubation with holotransferrin significantly inhibited the cyto-toxicity of ascorbate toward Molt-4 cells. High concentrations of iron may be responsible for the reduced efficacy of vitamin C in killing leukemia cells and may explain the contradictory results obtained from clinical studies.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms