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Current Trends in Medicinal Chemistry   Volumes    Volume 7 
Metal complexes of the antihypertensive drugs that inhibit the renin-angiotensin system
Patricia A. M. Williams
Pages: 97 - 104
Number of pages: 8
Current Trends in Medicinal Chemistry
Volume 7 

Copyright © 2013 Research Trends. All rights reserved

Hypertension affects nearly 1/3 of adult population worldwide. Several classes of medications are available to lower blood pressure including diuretics, β-blockers, calcium channel blockers (CCB) and the inhibitors of the renin-angiotensin system (RAS) such as renin inhibitors, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARB). Biometals are metal ions important for the vital functions of the living organisms and are able to chelate the administered medications and modify their structures. A great number of metal complexes of ACE inhibitors have been studied. Considering the recent development of the ARBs by rational drug design methods, it is important also to study metal complexes of the sartans family. The aim of this review is to describe the metal complexes of the ACE and ARB families and some of their biological properties.
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