The development of new processes for the production of micro- and nano particles of pharmaceuticals, polymers, catalysts and bio-materials may open  new perspectives in the manufacturing of high-tech commodities. Supercritical carbon dioxide based processes are proposed to fine and pure particulate production and can be a sound alternative to conventional processes, due to the unique physico-chemical properties of supercritical fluids that can overcome most of the drawbacks of the existing micronization techniques.

In this work supercritical fluids-based particle generation techniques are reviewed: emerging techniques, process mechanisms, experimental results, particle morphologies and perspectives of industrial application are critically examined and discussed.