The overstimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been implicated in the physiopathogenesis of epilepsy as well as in acute and chronic neurodegenerative disorders. In this paper we described an account of the synthesis of new 4-oxo-imidazo[l,2-a]indeno[l,2-e]pyrazin-8- and -9-carboxylic (phosphonic, acetic) acid derivatives. These compounds have demonstrated highly selective and potent AMPA antagonist activy in vivo.