This review presents the data published during 1990-2010 (161 references) dealing with the application of modern instrumental methods for analysis of catecholamine-based drugs. Such pharmaceuticals are widely used for the treatment of neuroblastoma, hypertension, bronchial asthma, schizophrenia, Parkinson’s disease and for the diagnostics of cardiac diseases. Hence, it is very important to control the quality of the catecholamine-based drugs. The present review is organized primarily according to analytical method type. Sensitivity, selectivity, precision, and other analytical characteristics of the developed procedures for the determination of natural and synthetic catecholamines in different pharmaceutical formulations are discussed. Particular attention has been paid to flow injection pharmaceutical analysis. The specific features of pretreatment of liquid and solid dosage forms are described. The problems and prospects of the chemical analysis of the officinal catecholamine-based drugs are considered.