Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 8 
Changes in mitochondrial function and ultrastructure during rat liver regeneration
Loredana Moro, Ersilia Marra, Margherita Greco
Pages: 29 - 40
Number of pages: 12
Current Topics in Biochemical Research
Volume 8 

Copyright © 2006 Research Trends. All rights reserved


This review deals with studies carried out to investigate changes in mitochondrial bioenergetic aspects and membrane functionality during the regenerative process that occurs in liver after partial resection (70%). Studies aimed at investigating changes in hepatocyte and mitochondria ultrastructure within the hepatic acinus during liver regeneration are also reported. In addition, the effect of thyroid state on the regenerative process will be considered. Partial hepatectomy induces cell proliferation until the original mass of the liver is restored. During the prereplicative phase of liver regeneration, drastic changes in the metabolism of the remaining liver occur, including impairment of mitochondrial bioenergetics and changes in the inner mitochondrial membrane permeability properties. Significant changes in the ultrastructure of hepatocytes and mitochondria in situ also occur, and a preferential zonation of altered mitochondria in periportal hepatocytes, the cells that exhibit major structural attributes to proliferate, is observed. Thyroid hormone serum levels influence the biochemical properties and the membrane functionality of mitochondria during liver regeneration. The involvement of mitochondria- mediated signaling in the modulation of the liver regenerative process is discussed.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms