Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 8 
Interactions between insulin-like growth factor receptor, E-cadherin/catenin complex and integrins. Role in cell migration
Erwann Gouranton, Frédéric Andre
Pages: 71 - 79
Number of pages: 9
Current Topics in Biochemical Research
Volume 8 

Copyright © 2006 Research Trends. All rights reserved

The insulin-like growth factor-I receptor (IGF-IR) is an ubiquitous multifunctional tyrosine kinase growth factor receptor that has been implicated in a wide variety of cellular functions including cell proliferation, cell differentiation, cell migration and apoptosis. Recent studies have shown that IGF-IR can promote cell motility by regulating both cell-cell adhesion and cell-extracellular matrix interactions. Thus, evidence is emerging that there may be molecular crosstalk between cell adhesion molecules such as E-cadherin and integrins and IGF-IR. The goal of this review is to introduce recent data concerning the physical and functional interactions between IGF-IR, integrins and E-cadherin. The existence of a supramolecular complex containing at least E-cadherin, IGF-IR and some integrins is discussed.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms