In this treatise we will examine lead deposition and its effects on the musculoskeletal system. The population remains at risk of lead exposure due to its continued use, persistence in the environment, and the release of lead from skeletal repositories back into the body’s soft tissues. Virtually all organ systems evaluated have proven susceptible to lead toxicity. Despite these findings, the skeleton was thought to be exempt from lead toxicity until very recently. Accumulating evidence shows that the musculoskeletal system is, in fact, susceptible to lead toxicity even at very low levels (5µg/dL). Lead-sensitive musculoskeletal components include: motor skills, bone growth and development, dentition, fracture healing, bone density, and joint maintenance. This organ system also seems to be vulnerable starting in utero through old age. Continued research in this area will identify novel strategies that may be used in the prevention and treatment of musculoskeletal disorders due to lead exposure.