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Current Topics in Toxicology   Volumes    Volume 8 
Abstract
Natural products: New anti-cancer agents derived from plants
Elizabet Estrada-Muñiz, Gabriela Guerrero-Palomo, Libia Vega
Pages: 19 - 32
Number of pages: 14
Current Topics in Toxicology
Volume 8 

Copyright © 2012 Research Trends. All rights reserved

ABSTRACT
 
Plants are a source of biologically-active compounds. They are used as crude material or pure compounds for cancer treatment. Besides these uses, such products are part of the integrative healthcare systems. Medicinal plants are formulated in different modern dosage forms, such as Cat’s claw (Uncaria tomentosa), Maca (Lepidium meyenii), Dragon`s blood (Croton lechleri), Acai palm (Euterpe oleracea), Noni (Morinda citrifolia) and Green tea. However, the use of medicinal plants in combination with conventional chemotherapeutics has significantly incremented the risk for adverse effects. Clinical data on interactions of medicinal plants with anti-cancer drugs contribute to the inter-individual variation, unexpected toxicities, and under-treatment seen in cancer patients. Based on the traditional use, or as part of systematic studies in the laboratory, plants and molecules with antitumor properties were studied; some of these plants are Calophyllum brasiliense and Garcinia mangostana, belonging to the family Clusiaceae. Juice of G. mangostana is sold as a dietary supplement with chemopreventive properties. Its effects are mainly attributed to xanthones, which inhibit cell proliferation, affect signaling pathways and induce apoptosis in different cell lines. Other xanthones are also present in C. brasiliense and are currently under study to determine their antitumor properties. All these features of xanthones make these compounds excellent candidates as anti-cancer agents and to study novel mechanisms of action that can be exploited as new therapeutic targets with fewer side effects, improve the patient’s quality of life and reduce costs in public and private health systems.
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