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Trends in Cell & Molecular Biology   Volumes    Volume 8 
Abstract
Phosphoinositide 3-kinase beta: when a kinase is more than a kinase
Javier Redondo-Muñoz, Vicente Pérez-García, Ana C. Carrera
Pages: 83 - 92
Number of pages: 10
Trends in Cell & Molecular Biology
Volume 8 

Copyright © 2013 Research Trends. All rights reserved

ABSTRACT
 
Phosphoinositide 3-kinases regulate numerous intracellular signals and essential biological processes; defects in their expression or regulation are implicated in diverse pathologies. For these reasons, research efforts have focused on generating inhibitors of the catalytic activity of these proteins. Recent evidence nonetheless indicates important non-catalytic properties for these kinases. These kinase-independent roles include a scaffold function in the organization of complexes with other proteins or with DNA, which suggests that pharmacological inhibition of phosphoinositide 3-kinase activity will not always result in loss of function.
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