Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Peptide & Protein Research   Volumes    Volume 9 
Abstract
Future aspects of tumor-associated antigen peptide immunization using epidermal Langerhans cells
Naohiro Seo
Pages: 27 - 35
Number of pages: 9
Current Topics in Peptide & Protein Research
Volume 9 

Copyright © 2008 Research Trends. All rights reserved

ABSTRACT
 
Acute disruption of the corneum barrier with adhesive tape resulted in enhanced permeability and alterations in the skin immune system in such a way that epidermal Langerhans cells (LCs) functioned as vigorous antigen presenters for cytotoxic T lymphocytes (CTLs). In both human and murine systems, topical application of tumor-associated antigen (TAA) peptides onto stratum corneum barrier-disrupted skin specifically induced tumoricidal immune responses in vivo and in vitro. In addition, for reasons of simplicity, safety and effectiveness, percutaneous peptide application has demonstrated a certain degree of feasibility in clinical approach in patients with melanomas. In the future, resolution of some of the outstanding issues regarding the selection of the most effective adjuvants in combination with barrier disruption, development of the effective methods of T helper (Th) 1 cell-mediated CTL induction, and depletion of regulatory T (Treg) cell-mediated immune suppression from tumor bearers would appear as essential for improvement of percutaneous TAA peptide immunization.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms