Herbal medicine has been used as preventive agents and for treatment of liver disorders in different cultures for hundreds of years. Medicinal plants show antipyretic, analgesic, anti-inflammatory, and anti-cancer effects. In addition, herbal medicine is used in nutrient supplement for anti-cancer and anti-inflammatory activity. Numerous in vitro and in vivo studies of herbal medicine have been reported on their beneficial effects. However, the mechanism of actions remains unclear. This review aims to give an overview on the hepato-protective effects of herbal medicine on liver functions. The report also covers the possible mode of actions of some of the herbal medicines. The common side effects of herbal medicine upon long-term use are discussed. Finally, the report sheds lights on the therapeutic benefits as an alternative medicine for treatment of liver disease and its potential use as a hepato-protective agent.