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Current Topics in Peptide & Protein Research   Volumes    Volume 1  Issue 1
Abstract
Multi-branched V3 peptides as HIV inhibitors
Jacques Fantini, Nouara Yahi, Kamel Mabrouk, Jurphaas Van Rietschoten, Herve Rochat, Jean-Marc Sabatier
Pages: 11 - 24
Number of pages: 14
Current Topics in Peptide & Protein Research
Volume 1  Issue 1

Copyright © 1994 Research Trends. All rights reserved

ABSTRACT
 
Synthetic polymeric constructions (SPCs) including the consensus sequence of the HIV-1 surface envelope glycoprotein gp120 V3 loop (GPGRAF) blocked the fusion between HIV-1 or HIV-2 infected cells and CD4+ uninfected cells. These SPCs also inhibited the infection of human CD4+ lymphocytes, macrophages, and CD4- intestinal cells, by unrelated isolates of HIV-1 and HIV-2. V3 SPCs represent therefore a new class of therapeutic agents which may inhibit the spread of a wide range of HIV isolates in infected individuals.
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