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Current Topics in Peptide & Protein Research   Volumes    Volume 1  Issue 1
Abstract
Nucleopeptides and other peptide-oligonucleotide conjugates
Jordi Robles, Maria Concernau, Enrique Pedroso, Anna Grandas
Pages: 151 - 158
Number of pages: 8
Current Topics in Peptide & Protein Research
Volume 1  Issue 1

Copyright © 1994 Research Trends. All rights reserved

ABSTRACT
 
The convenience of the use of either a convergent or a stepwise approach for the preparation of nucleopeptides is discussed. We describe the solid-phase synthesis of nucleopeptides H-Ser(pT)-Gly-Leu-NH2, Piv-Ser(pACGT)-Gly-Leu-NH2 and Phac-Ser(pCATCAT)-Gly-Asp-OH with a phosphate diester linkage between the peptide and the oligonucleotide, and the preparation of an analogue, Ac-Ser-Gly-Asp-NH-pT, with an acylphosphoramidate union.
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