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Current Topics in Peptide & Protein Research   Volumes    Volume 1  Issue 1
Multivalent carbohydrate-protein interactions. A new dimension of binding specificity
Dipti Gupta, C. Fred Brewer
Pages: 177 - 191
Number of pages: 15
Current Topics in Peptide & Protein Research
Volume 1  Issue 1

Copyright © 1994 Research Trends. All rights reserved

Binding of multivalent lectins to cell surfaces leads to aggregation and cross-linking of glycoprotein and glycolipid receptors which, in turn, is associated with a variety of biological signal transduction process including mitogenesis. We have recently demonstrated that the interactions of multivalent lectins with naturally occurring and synthetic branch chain oligosaccharides leads to the formation of homopolymeric lectin-carbohydrates cross-linked complexes, even in the presence of mixtures of the molecules. Glycoproteins have also been shown to form homoaggregated cross-linked complexes are crystalline and have been analyzed by electron microscopy and X-ray crystallography. The results reveal a new dimension of specificity in the interactions of lectins with glycoconjugates and important insights into their structure-function properties.
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